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Nordic Workshop on Statistical Physics: Biological, Complex and Non-equilibrium Systems
Nordic Workshop on Statistical Physics: Biological, Complex and Non-equilibrium Systems
17-19 March 2010 Nordita
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Metabolic Networks, Information, Null Model, and Evolution
 
The metabolism in an organism is reduced to a network of
substances. The resulting degree-distribution is power law
like with an exponent about 2.2. 
In order to understand this, we use information theory to
obtain a null-model defined by assigning equal probabilities
to what is assumed to be the fundamental network
possibilities. A stochastic variant of variational calculus
is used to obtain the corresponding degree distribution for
the null-model. The striking agreement implies that the null
model catches the overall feature of the metabolic network.
Using the network structure measures like clustering and
assortativity, a small difference is identified as the only
sign of any possible evolutionary pressure. However, this
difference is only manifested in a slight difference in the
degree distribution and seemingly not in any particular
network design.
 
Id: 268
Place: Nordita
Room: Nordita Seminar Room 132:028
Starting date:
19-Mar-2010   11:45
Duration: 45'
Presenters: MINNHAGEN, Petter
 
 

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